Stereoselective 1,2-Dicarbofunctionalization of Trisubstituted Alkenes by Palladium-Catalyzed Heck/Suzuki or Heck/Sonogashira Domino Sequence
نویسندگان
چکیده
منابع مشابه
A regio- and stereoselective synthesis of trisubstituted alkenes via gold(I)-catalyzed hydrophosphoryloxylation of haloalkynes.
A new stereoselective synthesis of trisubstituted alkenes is developed. Hydrophosphoryloxylation of haloalkynes provides Z-alkenyl halophosphates, which undergo Pd-catalyzed consecutive cross-coupling reactions to afford regio- and stereodefined trisubstituted alkenes.
متن کاملRemarkable access to fluoroalkylated trisubstituted alkenes via highly stereoselective cobalt-catalyzed hydrosilylation reaction of fluoroalkylated alkynes.
Hydrosilylation reaction of various fluoroalkylated alkynes with Et(3)SiH in the presence of a catalytic amount of Co(2)(CO)(8) was investigated. The hydrosilylation of the alkynes having fluoroalkyl and aryl groups took place smoothly with good regioselectivity (ca. 80:20). In sharp contrast, the reaction of the alkynes having a fluoroalkyl group and a benzyl-type substituent, or various propa...
متن کاملPalladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonate†
Efficient and straightforward methods for the synthesis of fluorinated compounds are increasingly important in the discovery of new biologically active molecules and advanced functional materials. Over the past few years, considerable efforts have been made in the fluoroalkylation of arenes, however efficient strategies for the synthesis of alkenes bearing fluorinated functional groups are less...
متن کاملAerobic palladium-catalyzed dioxygenation of alkenes enabled by catalytic nitrite.
Catalytic nitrite was found to enable carbon-oxygen bond-forming reductive elimination from unstable alkyl palladium intermediates, providing dioxygenated products from alkenes. A variety of functional groups were tolerated, and high yields (up to 94 %) were observed with many substrates, also for a multigram-scale reaction. Nitrogen dioxide, which could form from nitrite under the reaction con...
متن کاملAerobic oxidative amination of unactivated alkenes catalyzed by palladium.
The first examples of palladium-catalyzed oxidative amination of unactivated alkyl olefins have been identified. To be successful, these reactions must be conducted under cocatalyst-free conditions that involve direct dioxygen-coupled turnover of the palladium catalyst. The oxidative amination products of norbornene and other cyclic alkenes implicate a cis-aminopalladation mechanism.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CCS Chemistry
سال: 2020
ISSN: 2096-5745
DOI: 10.31635/ccschem.020.202000506